Eva Kosek
Professor vid Institutionen för kirurgiska vetenskaper; Klinisk smärtforskning
- E-post:
- eva.kosek@uu.se
- Besöksadress:
- Akademiska sjukhuset, ingång 70, 1tr
- Postadress:
- Akademiska sjukhuset, ingång 70, 1tr
751 85 UPPSALA
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Biografi
Denna text finns inte på svenska, därför visas den engelska versionen.
Dr. Kosek received her medical degree (MD) from Uppsala University in 1986 and her PhD from the Karolinska Institutet, Stockholm in 1996. She is a specialist in rehabilitation medicine since 1998 and pain relief since 2001 and has been clinically active for the most part of her professional carrier. She has carried out her research at the Karolinska Institutet, as Associate Professor since 2004 and full Professor of Clinical Pain Research since 2015. In 2020 she also became full Professor of Clinical Pain Research at the Department of Surgical Sciences, Uppsala University, combined with a position as senior consultant at the Pain Center, Uppsala University Hospital. She combines these three positions with the aim to facilitate collaborative research projects.
Prof Kosek chaired the International Association of Pain (IASP) Terminology Task Force, introducing a new pain mechanistic term “nociplastic pain” intended for primary pain syndromes characterized by altered nociception (i.e., dysfunctional pain modulation).
Forskning
Denna text finns inte på svenska, därför visas den engelska versionen.
Prof. Kosek’s research focuses on pathophysiological mechanisms in chronic musculoskeletal pain, with special reference to central pain modulation and neuroimmune interaction. She studies common pain disorders such as fibromyalgia, osteoarthritis, rheumatoid arthritis and various specific chronic low back pain conditions. The research is hypothesis driven and profits from a wide variety of techniques such as genetics, analysis of inflammatory substances in cerebrospinal fluid and blood, quantitative sensory testing and neuroimaging (functional magnetic resonance imaging, positron emission tomography). Prof Kosek has several national and international research collaborations and also participates in translational studies, currently mainly focusing on the role of autoreactive antibodies in fibromyalgia.
Link to research group: https://surgsci.uu.se/Forskning/forskningsomraden/klinisk-smartforskning/
Publikationer
Urval av publikationer
- Comorbid Conditions in Temporomandibular Disorders Myalgia and Myofascial Pain Compared to Fibromyalgia (2021)
- Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls (2021)
- Polymorphisms of the μ-opioid receptor gene influence cerebral pain processing in fibromyalgia (2021)
- Passive transfer of fibromyalgia symptoms from patients to mice (2021)
- Is Europe also facing an opioid crisis? (2021)
- Classification algorithm for the International Classification of Diseases-11 chronic pain classification (2021)
- Central sensitisation in chronic pain conditions (2021)
- Expression of mitochondrial TSPO and FAM173B is associated with inflammation and symptoms in patients with painful knee osteoarthritis (2021)
- Fibromyalgia position paper (2021)
- Objective and Subjective Sleep in Rheumatoid Arthritis and Severe Seasonal Allergy (2021)
- Plasma tryptophan and kynurenine in females with temporomandibular disorders and fibromyalgia-An exploratory pilot study. (2020)
- Elevated inflammatory proteins in cerebrospinal fluid from patients with painful knee osteoarthritis are associated with reduced symptom severity (2020)
- Neural correlates of conditioned pain responses in fibromyalgia subjects indicate preferential formation of new pain associations rather than extinction of irrelevant ones. (2020)
- Increased Anandamide and Decreased Pain and Depression after Exercise in Fibromyalgia. (2020)
- Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia. (2020)
- NF-κB-Associated Pain-Related Neuropeptide Expression in Patients with Degenerative Disc Disease. (2019)
- Brain glial activation in fibromyalgia (2019)
- The human CSF pain proteome (2019)
- Disease activity in rheumatoid arthritis is inversely related to cerebral TSPO binding assessed by [11C]PBR28 positron emission tomography (2019)
- Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise. (2019)
- Tooth Clenching Until Exhaustion Evokes Exercise-Induced Hypoalgesia in Healthy Persons and in Patients with Temporomandibular Disorders. (2019)
- Characterization of neuroinflammation and periphery-to-CNS inflammatory cross-talk in patients with disc herniation and degenerative disc disease. (2019)
- Accuracy and reliability of [C-11]PBR28 specific binding estimated without the use of a reference region (2019)
- Exercise-Induced Hypoalgesia in Pain-Free and Chronic Pain Populations (2019)
- Altered cerebral pain processing of noxious stimuli from inflamed joints in rheumatoid arthritis (2019)
- The IASP classification of chronic pain for ICD-11 (2019)
- Chronic pain as a symptom or a disease (2019)
- Effects of age, BMI and sex on the glial cell marker TSPO (2019)
- Activation of NF-kappa B in Synovium versus Cartilage from Patients with Advanced Knee Osteoarthritis (2018)
- Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy. (2018)
- Differences in neuroimmune signalling between male and female patients suffering from knee osteoarthritis. (2018)
- Controlled, cross-sectional, multi-center study of physical capacity and associated factors in women with fibromyalgia. (2018)
- Long-term, health-enhancing physical activity is associated with reduction of pain but not pain sensitivity or improved exercise-induced hypoalgesia in persons with rheumatoid arthritis. (2018)
- Pain sensitivity at rest and during muscle contraction in persons with rheumatoid arthritis (2018)
- The role of long-term physical exercise on performance and brain activation during the Stroop colour word task in fibromyalgia patients. (2018)
- Exploring cerebrospinal fluid proteome in fibromyalgia (2018)
- The Relationship of Endocannabinoidome Lipid Mediators With Pain and Psychological Stress in Women With Fibromyalgia (2018)
- Evidence of fatigue, disordered sleep and peripheral inflammation, but not increased brain TSPO expression, in seasonal allergy (2018)
- Benefits of resistance exercise in lean women with fibromyalgia (2017)
- Lower Placebo Responses After Long-Term Exposure to Fibromyalgia Pain. (2017)
- Pain and fear avoidance partially mediate change in muscle strength during resistance exercise in women with fibromyalgia. (2017)
- EULAR revised recommendations for the management of fibromyalgia. (2017)
- Gene-to-gene interactions regulate endogenous pain modulation in fibromyalgia patients and healthy controls-antagonistic effects between opioid and serotonin-related genes. (2017)
- Resistance exercise improves physical fatigue in women with fibromyalgia (2016)
- Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia. (2016)
- Intrinsic Brain Connectivity in Chronic Pain (2016)
- Increased Interstitial Concentrations of Glutamate and Pyruvate in Vastus Lateralis of Women with Fibromyalgia Syndrome Are Normalized after an Exercise Intervention - A Case-Control Study. (2016)
- In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects (2016)
- Why sickness hurts (2016)
- Do we need a third mechanistic descriptor for chronic pain states? (2016)
- The translocator protein gene is associated with symptom severity and cerebral pain processing in fibromyalgia. (2016)
- Are there different predictors of analgesic response between antidepressants and anticonvulsants in painful diabetic neuropathy? (2016)
- Decrease of fear avoidance beliefs following person-centered progressive resistance exercise contributes to reduced pain disability in women with fibromyalgia (2016)
- Comparison of the Levels of Pro-Inflammatory Cytokines Released in the Vastus Lateralis Muscle of Patients with Fibromyalgia and Healthy Controls during Contractions of the Quadriceps Muscle--A Microdialysis Study. (2015)
- Normalization of aberrant resting state functional connectivity in fibromyalgia patients following a three month physical exercise therapy. (2015)
- Systemic differences in serum metabolome (2015)
- Modality and sex differences in pain sensitivity during human endotoxemia. (2015)
- Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain--interleukin-8 in fibromyalgia and interleukin-1 β in rheumatoid arthritis. (2015)
- Resistance exercise improves muscle strength, health status and pain intensity in fibromyalgia--a randomized controlled trial. (2015)
- A classification of chronic pain for ICD-11. (2015)
- Neuropathic pain phenotyping as a predictor of treatment response in painful diabetic neuropathy (2014)
- Fibromyalgia is associated with decreased connectivity between pain- and sensorimotor brain areas. (2014)
- Segregating the cerebral mechanisms of antidepressants and placebo in fibromyalgia. (2014)
- Fibromyalgia patients had normal distraction related pain inhibition but cognitive impairment reflected in caudate nucleus and hippocampus during the Stroop Color Word Test. (2014)
- Perceived exertion at work in women with fibromyalgia (2014)
- Effects of neuromuscular training (NEMEX-TJR) on patient-reported outcomes and physical function in severe primary hip or knee osteoarthritis (2013)
- Higher pain sensitivity and lower muscle strength in postmenonpausal women with early rheumatoid arthritis compared with age-matched healthy women--a pilot study. (2013)
- Overlapping structural and functional brain changes in patients with long-term exposure to fibromyalgia pain. (2013)
- Increased pain sensitivity but normal function of exercise induced analgesia in hip and knee osteoarthritis--treatment effects of neuromuscular exercise and total joint replacement. (2013)
- Using fMRI to evaluate the effects of milnacipran on central pain processing in patients with fibromyalgia. (2013)
- Acceptance and commitment therapy for fibromyalgia (2013)
- Cognitive Behavioral Therapy increases pain-evoked activation of the prefrontal cortex in patients with fibromyalgia. (2012)
- Patients with fibromyalgia display less functional connectivity in the brain's pain inhibitory network. (2012)
- Evidence of central inflammation in fibromyalgia-increased cerebrospinal fluid interleukin-8 levels. (2012)
- Spontaneous pain is reduced by conditioning pain modulation in peripheral neuropathy but not in fibromyalgia-Implications for different pain mechanisms. (2012)
- Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice. (2012)
- Serotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception. (2012)
- Dysfunctional endogenous analgesia during exercise in patients with chronic pain (2012)
- Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene. (2011)
- Evidence for thalamic involvement in the thermal grill illusion (2011)
- Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene. (2011)
- Anxiety and depressive symptoms in fibromyalgia are related to poor perception of health but not to pain sensitivity or cerebral processing of pain. (2010)
- Evidence of reduced sympatho-adrenal and hypothalamic-pituitary activity during static muscular work in patients with fibromyalgia. (2010)
- Dysfunction of endogenous pain inhibition during exercise with painful muscles in patients with shoulder myalgia and fibromyalgia. (2010)
- Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain. (2009)
- Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism. (2009)
- Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid Remifentanil in humans. (2009)
- EULAR evidence-based recommendations for the management of fibromyalgia syndrome. (2008)
- Mechanisms of pain referral in patients with whiplash-associated disorder. (2008)
- The effects of static muscular contraction on blood pressure, heart rate, pain ratings and pressure pain thresholds in healthy individuals and patients with fibromyalgia. (2007)
- Comparison of vibration perception thresholds in individuals with diffuse upper limb pain and carpal tunnel syndrome. (2007)
- Decreased muscle blood flow in fibromyalgia patients during standardised muscle exercise (2006)
- Perceptual integration of intramuscular electrical stimulation in the focal and the referred pain area in healthy humans. (2003)
- Segmental and plurisegmental modulation of pressure pain thresholds during static muscle contractions in healthy individuals. (2003)
- Somatosensory perception in patients suffering from long-term trapezius myalgia at the site overlying the most painful part of the muscle and in an area of pain referral. (2003)
- Quantitative and qualitative perceptual analysis of cold dysesthesia and hyperalgesia in fibromyalgia. (2002)
- The influence of experimental pain intensity in the local and referred pain area on somatosensory perception in the area of referred pain. (2002)
- Somatosensory perception in a remote pain-free area and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from long-term trapezius myalgia. (2002)
- Somatosensory perception and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from rheumatoid arthritis. (2002)
- Abnormalities of somatosensory perception in patients with painful osteoarthritis normalize following successful treatment. (2000)
- Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief. (2000)
- Injection of hypertonic saline into musculus infraspinatus resulted in referred pain and sensory disturbances in the ipsilateral upper arm. (2000)
- The influence of pain intensity on somatosensory perception in patients suffering from subacute/chronic lateral epicondylalgia. (2000)
- Pressure pain thresholds in different tissues in one body region. The influence of skin sensitivity in pressure algometry. (1999)
- Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects. (1997)
- Sensory dysfunction in fibromyalgia patients with implications for pathogenic mechanisms. (1996)
- Modulation of pressure pain thresholds during and following isometric contraction in patients with fibromyalgia and in healthy controls. (1996)
- Modulation of pressure pain thresholds during and following isometric contraction. (1995)
Senaste publikationer
- Analgesic efficacy of sleep-promoting pharmacotherapy in patients with chronic pain (2023)
- Anti-satellite glia cell IgG antibodies in fibromyalgia patients are related to symptom severity and to metabolite concentrations in thalamus and rostral anterior cingulate cortex. (2023)
- The Vastus Lateralis Muscle Interstitium Proteome Changes after an Acute Nociception in Patients with Fibromyalgia Compared to Healthy Subjects-A Microdialysis Study (2023)
- Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases (2023)
- Reply to Hoegh et al. (2023)
Alla publikationer
Artiklar
- Analgesic efficacy of sleep-promoting pharmacotherapy in patients with chronic pain (2023)
- Anti-satellite glia cell IgG antibodies in fibromyalgia patients are related to symptom severity and to metabolite concentrations in thalamus and rostral anterior cingulate cortex. (2023)
- The Vastus Lateralis Muscle Interstitium Proteome Changes after an Acute Nociception in Patients with Fibromyalgia Compared to Healthy Subjects-A Microdialysis Study (2023)
- Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases (2023)
- Reply to Hoegh et al. (2023)
- Fibromyalgia patients with elevated levels of anti-satellite glia cell immunoglobulin G antibodies present with more severe symptoms (2023)
- Reply on (2023)
- The effects of a 15-week physical exercise intervention on pain modulation in fibromyalgia (2023)
- Reply to (2023)
- Emotion regulation and the salience network (2023)
- Reply to 'Imbalance of threat and soothing systems in fibromyalgia (2023)
- Neurophysiological and psychosocial mechanisms of fibromyalgia (2023)
- Dysfunctional Activation of the Dorsolateral Prefrontal Cortex During Pain Anticipation Is Associated With Altered Subsequent Pain Experience in Fibromyalgia Patients (2023)
- Multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis (2022)
- The translocator protein gene is associated with endogenous pain modulation and the balance between glutamate and gamma-aminobutyric acid in fibromyalgia and healthy subjects (2022)
- Swedish Chronic Pain Biobank (2022)
- Concerns about the taxonomy, definition and coding of fibromyalgia syndrome in ICD-11 (2022)
- Lysophophatidylcholine 16:0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3 (2022)
- Reply to Cohen (2022)
- International, multidisciplinary Delphi consensus recommendations on non-pharmacological interventions for fibromyalgia (2022)
- Augmented pain inhibition and higher integration of pain modulatory brain networks in women with self-injury behavior (2022)
- Non-Peptide Opioids Differ in Effects on Mu-Opioid (MOP) and Serotonin 1A (5-HT1A) Receptors Heterodimerization and Cellular Effectors (Ca2+, ERK 1/2 and p38) Activation (2022)
- Distinct aberrations in cerebral pain processing differentiating patients with fibromyalgia from patients with rheumatoid arthritis (2022)
- Features and methods to discriminate between mechanism-based categories of pain experienced in the musculoskeletal system (2022)
- The OPRM1 gene and interactions with the 5-HT1a gene regulate conditioned pain modulation in fibromyalgia patients and healthy controls (2022)
- Proteomic Investigation in Plasma from Women with Fibromyalgia in Response to a 15-wk Resistance Exercise Intervention (2022)
- Comorbid Conditions in Temporomandibular Disorders Myalgia and Myofascial Pain Compared to Fibromyalgia (2021)
- Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls (2021)
- Polymorphisms of the μ-opioid receptor gene influence cerebral pain processing in fibromyalgia (2021)
- Research Recommendations Following the Discovery of Pain Sensitizing IgG Autoantibodies in Fibromyalgia Syndrome (2021)
- Passive transfer of fibromyalgia symptoms from patients to mice (2021)
- Is Europe also facing an opioid crisis? (2021)
- Classification algorithm for the International Classification of Diseases-11 chronic pain classification (2021)
- Chronic nociplastic pain affecting the musculoskeletal system (2021)
- Central sensitisation in chronic pain conditions (2021)
- Expression of mitochondrial TSPO and FAM173B is associated with inflammation and symptoms in patients with painful knee osteoarthritis (2021)
- Diagnostic and therapeutic care pathway for fibromyalgia (2021)
- Fibromyalgia position paper (2021)
- Objective and Subjective Sleep in Rheumatoid Arthritis and Severe Seasonal Allergy (2021)
- Plasma tryptophan and kynurenine in females with temporomandibular disorders and fibromyalgia-An exploratory pilot study. (2020)
- Elevated inflammatory proteins in cerebrospinal fluid from patients with painful knee osteoarthritis are associated with reduced symptom severity (2020)
- Neural correlates of conditioned pain responses in fibromyalgia subjects indicate preferential formation of new pain associations rather than extinction of irrelevant ones. (2020)
- Increased Anandamide and Decreased Pain and Depression after Exercise in Fibromyalgia. (2020)
- Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia. (2020)
- NF-κB-Associated Pain-Related Neuropeptide Expression in Patients with Degenerative Disc Disease. (2019)
- Brain glial activation in fibromyalgia (2019)
- The human CSF pain proteome (2019)
- Disease activity in rheumatoid arthritis is inversely related to cerebral TSPO binding assessed by [11C]PBR28 positron emission tomography (2019)
- Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise. (2019)
- Tooth Clenching Until Exhaustion Evokes Exercise-Induced Hypoalgesia in Healthy Persons and in Patients with Temporomandibular Disorders. (2019)
- Characterization of neuroinflammation and periphery-to-CNS inflammatory cross-talk in patients with disc herniation and degenerative disc disease. (2019)
- Accuracy and reliability of [C-11]PBR28 specific binding estimated without the use of a reference region (2019)
- Exercise-Induced Hypoalgesia in Pain-Free and Chronic Pain Populations (2019)
- Altered cerebral pain processing of noxious stimuli from inflamed joints in rheumatoid arthritis (2019)
- The IASP classification of chronic pain for ICD-11 (2019)
- Chronic pain as a symptom or a disease (2019)
- Effects of age, BMI and sex on the glial cell marker TSPO (2019)
- Activation of NF-kappa B in Synovium versus Cartilage from Patients with Advanced Knee Osteoarthritis (2018)
- Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy. (2018)
- Differences in neuroimmune signalling between male and female patients suffering from knee osteoarthritis. (2018)
- Controlled, cross-sectional, multi-center study of physical capacity and associated factors in women with fibromyalgia. (2018)
- Long-term, health-enhancing physical activity is associated with reduction of pain but not pain sensitivity or improved exercise-induced hypoalgesia in persons with rheumatoid arthritis. (2018)
- Pain sensitivity at rest and during muscle contraction in persons with rheumatoid arthritis (2018)
- The role of long-term physical exercise on performance and brain activation during the Stroop colour word task in fibromyalgia patients. (2018)
- Exploring cerebrospinal fluid proteome in fibromyalgia (2018)
- The Relationship of Endocannabinoidome Lipid Mediators With Pain and Psychological Stress in Women With Fibromyalgia (2018)
- Evidence of fatigue, disordered sleep and peripheral inflammation, but not increased brain TSPO expression, in seasonal allergy (2018)
- Benefits of resistance exercise in lean women with fibromyalgia (2017)
- Lower Placebo Responses After Long-Term Exposure to Fibromyalgia Pain. (2017)
- Pain and fear avoidance partially mediate change in muscle strength during resistance exercise in women with fibromyalgia. (2017)
- EULAR revised recommendations for the management of fibromyalgia. (2017)
- Gene-to-gene interactions regulate endogenous pain modulation in fibromyalgia patients and healthy controls-antagonistic effects between opioid and serotonin-related genes. (2017)
- Resistance exercise improves physical fatigue in women with fibromyalgia (2016)
- Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia. (2016)
- Intrinsic Brain Connectivity in Chronic Pain (2016)
- Increased Interstitial Concentrations of Glutamate and Pyruvate in Vastus Lateralis of Women with Fibromyalgia Syndrome Are Normalized after an Exercise Intervention - A Case-Control Study. (2016)
- In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects (2016)
- Why sickness hurts (2016)
- Do we need a third mechanistic descriptor for chronic pain states? (2016)
- The translocator protein gene is associated with symptom severity and cerebral pain processing in fibromyalgia. (2016)
- Are there different predictors of analgesic response between antidepressants and anticonvulsants in painful diabetic neuropathy? (2016)
- Decrease of fear avoidance beliefs following person-centered progressive resistance exercise contributes to reduced pain disability in women with fibromyalgia (2016)
- Comparison of the Levels of Pro-Inflammatory Cytokines Released in the Vastus Lateralis Muscle of Patients with Fibromyalgia and Healthy Controls during Contractions of the Quadriceps Muscle--A Microdialysis Study. (2015)
- Normalization of aberrant resting state functional connectivity in fibromyalgia patients following a three month physical exercise therapy. (2015)
- Systemic differences in serum metabolome (2015)
- Modality and sex differences in pain sensitivity during human endotoxemia. (2015)
- Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain--interleukin-8 in fibromyalgia and interleukin-1 β in rheumatoid arthritis. (2015)
- Resistance exercise improves muscle strength, health status and pain intensity in fibromyalgia--a randomized controlled trial. (2015)
- A classification of chronic pain for ICD-11. (2015)
- Neuropathic pain phenotyping as a predictor of treatment response in painful diabetic neuropathy (2014)
- Fibromyalgia is associated with decreased connectivity between pain- and sensorimotor brain areas. (2014)
- Segregating the cerebral mechanisms of antidepressants and placebo in fibromyalgia. (2014)
- Fibromyalgia patients had normal distraction related pain inhibition but cognitive impairment reflected in caudate nucleus and hippocampus during the Stroop Color Word Test. (2014)
- Perceived exertion at work in women with fibromyalgia (2014)
- Effects of neuromuscular training (NEMEX-TJR) on patient-reported outcomes and physical function in severe primary hip or knee osteoarthritis (2013)
- Higher pain sensitivity and lower muscle strength in postmenonpausal women with early rheumatoid arthritis compared with age-matched healthy women--a pilot study. (2013)
- Overlapping structural and functional brain changes in patients with long-term exposure to fibromyalgia pain. (2013)
- Increased pain sensitivity but normal function of exercise induced analgesia in hip and knee osteoarthritis--treatment effects of neuromuscular exercise and total joint replacement. (2013)
- Using fMRI to evaluate the effects of milnacipran on central pain processing in patients with fibromyalgia. (2013)
- Acceptance and commitment therapy for fibromyalgia (2013)
- Cognitive Behavioral Therapy increases pain-evoked activation of the prefrontal cortex in patients with fibromyalgia. (2012)
- Patients with fibromyalgia display less functional connectivity in the brain's pain inhibitory network. (2012)
- Evidence of central inflammation in fibromyalgia-increased cerebrospinal fluid interleukin-8 levels. (2012)
- Spontaneous pain is reduced by conditioning pain modulation in peripheral neuropathy but not in fibromyalgia-Implications for different pain mechanisms. (2012)
- Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice. (2012)
- Serotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception. (2012)
- Dysfunctional endogenous analgesia during exercise in patients with chronic pain (2012)
- Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene. (2011)
- Evidence for thalamic involvement in the thermal grill illusion (2011)
- Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene. (2011)
- Anxiety and depressive symptoms in fibromyalgia are related to poor perception of health but not to pain sensitivity or cerebral processing of pain. (2010)
- Evidence of reduced sympatho-adrenal and hypothalamic-pituitary activity during static muscular work in patients with fibromyalgia. (2010)
- Dysfunction of endogenous pain inhibition during exercise with painful muscles in patients with shoulder myalgia and fibromyalgia. (2010)
- Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain. (2009)
- Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism. (2009)
- Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid Remifentanil in humans. (2009)
- EULAR evidence-based recommendations for the management of fibromyalgia syndrome. (2008)
- Mechanisms of pain referral in patients with whiplash-associated disorder. (2008)
- The effects of static muscular contraction on blood pressure, heart rate, pain ratings and pressure pain thresholds in healthy individuals and patients with fibromyalgia. (2007)
- Comparison of vibration perception thresholds in individuals with diffuse upper limb pain and carpal tunnel syndrome. (2007)
- Decreased muscle blood flow in fibromyalgia patients during standardised muscle exercise (2006)
- Perceptual integration of intramuscular electrical stimulation in the focal and the referred pain area in healthy humans. (2003)
- Segmental and plurisegmental modulation of pressure pain thresholds during static muscle contractions in healthy individuals. (2003)
- Somatosensory perception in patients suffering from long-term trapezius myalgia at the site overlying the most painful part of the muscle and in an area of pain referral. (2003)
- Quantitative and qualitative perceptual analysis of cold dysesthesia and hyperalgesia in fibromyalgia. (2002)
- The influence of experimental pain intensity in the local and referred pain area on somatosensory perception in the area of referred pain. (2002)
- Somatosensory perception in a remote pain-free area and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from long-term trapezius myalgia. (2002)
- Somatosensory perception and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from rheumatoid arthritis. (2002)
- Abnormalities of somatosensory perception in patients with painful osteoarthritis normalize following successful treatment. (2000)
- Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief. (2000)
- Injection of hypertonic saline into musculus infraspinatus resulted in referred pain and sensory disturbances in the ipsilateral upper arm. (2000)
- The influence of pain intensity on somatosensory perception in patients suffering from subacute/chronic lateral epicondylalgia. (2000)
- Pressure pain thresholds in different tissues in one body region. The influence of skin sensitivity in pressure algometry. (1999)
- Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects. (1997)
- Sensory dysfunction in fibromyalgia patients with implications for pathogenic mechanisms. (1996)
- Modulation of pressure pain thresholds during and following isometric contraction in patients with fibromyalgia and in healthy controls. (1996)
- Modulation of pressure pain thresholds during and following isometric contraction. (1995)