Mattias Paulsson
Affilierad Forskare vid Institutionen för kvinnors och barns hälsa; Barnonkologisk forskning - särskilt fokus på komplikationer
- Telefon:
- 018-611 37 33
- E-post:
- mattias.paulsson@uu.se
- Besöksadress:
- MTC-huset, Dag Hammarskjölds väg 14B, 1 tr
752 37 Uppsala - Postadress:
- Akademiska sjukhuset
751 85 UPPSALA - Tillgänglig:
- Kvinnokliniken
- Akademiska meriter:
- apot.
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Kort presentation
Licensed pharmacist with a PhD in pharmaceutics. Experience from regulatory, GMP, quality, R&D, compounding, chemotherapy, radiopharmaceuticals. Hospital pharmacy.
Qualified Person Pharmacovigilance for Fludeoxyglucose (18F) Akademiska sjukhuset
Specialties: Pharmaceutics, disperse systems, gels, parenteral nutrition, aseptic compounding.
Nyckelord
- clinical nutrition
- clinical pharmacy
- formulation
- immuno-oncology
- protein drug
- radionuclides
Biografi
Mattias Paulsson obtained his pharmacist degree at Uppsala University, Sweden, in 1997. Thereafter he started his PhD project at the Department of Pharmacy/ Pharmaceutics, Uppsala University presenting his thesis “Controlled Release Gel Formulations for Mucosal Drug Delivery” in 2001. In the thesis, physicochemical principles of pharmacy are used for formulation development for clinical applications.
Dr. Paulsson has held positions as formulation scientist at both Cederroth International and Fresenius Kabi. He has been heading the extemporaneous compounding unit of Uppsala University Hospital, preparing radiopharmaceuticals, chemotherapy and other aseptically prepared medications as well as managing the clinical trials unit. He has been a qualified person and held positions with GMP-responsibility for compounding units at some Swedish hospitals.
In 2014 he started working with a more clinical approach at the Uppsala University Children’s Hospital with patient safety and optimizing the use of medications from a formulation point of view. He has configured and developed the medication modules of the PDMS system (MetaVision) used at the hospital including the NICU. He holds the position of QPPV (Qualified person pharmacovigilance) for the PET centre at the hospital. He has been managing projects to build new clean rooms, hire staff, purchasing equipment (including chemotherapy robotic automation) and in-sourcing of extemporaneous compounding units for radiotherapy, chemotherapy and miscellaneous aseptic preparations. From 2019 he is deputy chief pharmacist at Uppsala University Hospital and has several research projects running in 3D-printing and protein drug handling, including the EU/EFPIA Innovative Medicines Initiative 2 Joint Un-dertaking (RealHOPE grant).
He is involved in both undergraduate and post graduate training of pharmacist at Uppsala University and in some occasions also in Scandinavian settings in the areas: Parenteral nutrition, IV compatibility, Formulation Science and Compounding. He is supervising one PhD student at the department of Pharmacy, Uppsala university and became Associate professor (Docent) in March 2023.
He has been chairman for the Scandinavian Paediatric Pharmacist Group for 2017-2019 and he was in the steering committee of the ePed Best practice initiative (www.eped.se) for safe handling of paediatric medications based on the EU resolution on medication handling quality. He is a member of UK based Neonatal and Paediatric Pharmacists Group (NPPG) and the Swedish Pharmaceutical Society.
Forskning
The research questions of Mattias Paulsson focuses on complexities of paediatric medicine administration, addressing the lack of appropriately formulated drugs for children and the challenges associated. The use of new techniques such as additive manufacturing (3D-printing) is evaluated in a multiprofessional, clinically-oriented setting.
Paulsson is also engaged in research closely related to the neonatal intensive care unit and the latest published study explores the effects of different light conditions on oxidative stress markers, providing insights into potential measures to safeguard the nutritional integrity of breast milk for preterm infants.
Paulsson is also part of a European IMI project, RealHOPE, that explores the handling of protein drugs, particularly monoclonal antibodies used in paediatric oncology, emphasizing careful management. Research questions revolve around risk analyses, targeting stress factors affecting drug integrity during the handling/supply chain aiming at mitigating potential threats, including temperature and shock exposure to ensure the quality and safety of protein drugs.
The RealHOPE, a 4 year research project that aims to measure real-life events during drug handling to develop methods for simulating these events. Aiming to propose best practices to hospitals and hospital pharmacies for handling of protein drugs. RealHOPE consist of five work packages that each addresses the five project goals set for the project. The third work package is called HIGH and it will demonstrate and/or have develop new technologies for safer handling of protein drugs at hospital pharmacies. The project team will look at the methods and guidelines in use to improve the handling of drugs in hospital.
Please read more here: RealHOPE |
Media
Linkedin-profil
https://www.linkedin.com/in/mattias-paulsson-1957239/
Publikationer
Senaste publikationer
- Semisolid extrusion manufactured tablets with modifiable doses using off-the-shelf medication of metoprolol tartrate. (2024)
- How are we handling protein drugs in hospitals? (2024)
- Preparing paediatric medicines by dissolving tablets and extracting a portion may compromise dosing accuracy (2023)
- Lipid Peroxidation and Antioxidative Capacity Are Unaltered in Transitional Breast Milk Exposed to Light from Women Giving Birth to Preterm Infants before 32 Weeks of Gestation (2023)
- Dataset for Article: Lipid Peroxidation and Antioxidative Capacity Are Unaltered in Transitional Breast Milk Exposed to Light from Women Giving Birth to Preterm of Gestation (2023)
Alla publikationer
Artiklar
- How are we handling protein drugs in hospitals? (2024)
- Preparing paediatric medicines by dissolving tablets and extracting a portion may compromise dosing accuracy (2023)
- Lipid Peroxidation and Antioxidative Capacity Are Unaltered in Transitional Breast Milk Exposed to Light from Women Giving Birth to Preterm Infants before 32 Weeks of Gestation (2023)
- Examination of the Protein Drug Supply Chain in a Swedish University Hospital (2023)
- Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden: Need for personalized dosage forms (2022)
- Outdoor environmental effects on cleanrooms – A study from a Swedish hospital pharmacy compounding unit (2022)
- Manipulations of Oral Medications in Paediatric Neurology and Oncology Care at a Swedish University Hospital (2021)
- The Risk of Necrotizing Enterocolitis following the Administration of Hyperosmolar Enteral Medications to Extremely Preterm Infants (2021)
- Factors Influencing Breast Milk Fat Loss during Administration in the Neonatal Intensive Care Unit (2021)
- Improved Outcome of Intestinal Failure in Preterm Infants (2020)
- Parenteral nutrition (2020)
- Cost-Consequences Analysis of Increased Utilization of Triple-Chamber-Bag Parenteral Nutrition in Preterm Neonates in Seven European Countries (2020)
- Improved outcome in neonatal short bowel syndrome using parenteral fish oil in combination With ω-6/9 Lipid Emulsions (2012)
- Prevention and reversal of intestinal failure-associated liver disease in premature infants with short bowel syndrome using intravenous fish oil in combination with omega-6/9 lipid emulsions (2011)
- Catanionic drug-surfactant mixtures (2003)
- Controlled Drug Release from Gels Using Lipophilic Interactions of Charged Substances with Surfactants and Polymers (2002)
- Evaluation of drug release from gels on pig nasal mucosa in a horizontal Ussing chamber (2002)
- Controlled drug release from gels using surfactant aggregates (2001)
- Controlled drug release from gels using surfactant aggregates (2001)
- Evaluation of mucoadhesion for two polyelectrolyte gels in simulated physiological conditions using a rheological method (2000)
- Rheological studies of the gelation of deacetylated gellan gum (Gelrite®) in physiological conditions (1999)
- Colloidal and Thermal Characteristics of Concentrated Dispersions of Polymethacrylate-Based Latices for Aqueous Enteric Coating (1999)