Patrick Micke
Professor Docent vid Institutionen för immunologi, genetik och patologi; Forskningsprogram: Cancerimmunterapi; Forskargrupp Patrick Micke
- Telefon:
- 018-611 26 15
- Fax:
- 018-55 33 54
- E-post:
- patrick.micke@igp.uu.se
- Besöksadress:
- Dag Hammarskjölds väg 20
751 85 Uppsala - Postadress:
- Rudbecklaboratoriet
751 85 UPPSALA
- Akademiska meriter:
- docent
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Publikationer
Senaste publikationer
- Tumor Heterogeneity Confounds Lymphocyte Metrics in Diagnostic Lung Cancer Biopsies (2024)
- Distinct microRNA Signature and Suppression of ZFP36L1 Define ASCL1-Positive Lung Adenocarcinoma (2024)
- Spatial immunophenotyping of the tumour microenvironment in non-small cell lung cancer (2023)
- Phenotypic characterization of spatial immune infiltration niches in non-small cell lung cancer (2023)
- Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer (2023)
Alla publikationer
Artiklar
- Tumor Heterogeneity Confounds Lymphocyte Metrics in Diagnostic Lung Cancer Biopsies (2024)
- Distinct microRNA Signature and Suppression of ZFP36L1 Define ASCL1-Positive Lung Adenocarcinoma (2024)
- Spatial immunophenotyping of the tumour microenvironment in non-small cell lung cancer (2023)
- Phenotypic characterization of spatial immune infiltration niches in non-small cell lung cancer (2023)
- Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer (2023)
- An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers (2023)
- Fibroblast subsets in non-small cell lung cancer (2023)
- Matched Analyses of Brain Metastases versus Primary Non-Small Cell Lung Cancer Reveal a Unique microRNA Signature (2023)
- Difficulties in diagnostics of lung tumours in biopsies (2022)
- Spatial Immunology in Liver Metastases from Colorectal Carcinoma according to the Histologic Growth Pattern (2022)
- A Novel Pancreatic Cancer Mini-tumor Model to Study Desmoplasia and Myofibroblastic Cancer-Associated Fibroblast Differentiation (2022)
- Highly elevated systemic inflammation is a strong independent predictor of early mortality in advanced non-small cell lung cancer (2022)
- Prognostic Significance of the Loss of Heterozygosity of KRAS in Early-Stage Lung Adenocarcinoma (2022)
- Expression of cartilage oligomeric matrix protein in periampullary adenocarcinoma is associated with pancreatobiliary-type morphology, higher levels of fibrosis and immune cell exclusion (2022)
- Tumour-infiltrating lymphocytes add prognostic information for patients with low-risk DCIS (2022)
- Comparison of ROS1-rearrangement detection methods in a cohort of surgically resected non-small cell lung carcinomas. (2022)
- Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer (2021)
- Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection (2021)
- FGFR1 overexpression in non-small cell lung cancer is mediated by genetic and epigenetic mechanisms and is a determinant of FGFR1 inhibitor response (2021)
- Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene (2021)
- Evaluation of NTRK immunohistochemistry as a screening method for NTRK gene fusion detection in non-small cell lung cancer (2021)
- Plasma Proteomic Analysis in Non-Small Cell Lung Cancer Patients Treated with PD-1/PD-L1 Blockade (2021)
- PD-L1 amplification is associated with an immune cell rich phenotype in squamous cell cancer of the lung (2021)
- Targeting MARCO and IL-37R on immunosuppressive macrophages in lung cancer blocks regulatory T cells and supports cytotoxic lymphocyte function (2021)
- The Immune Landscape of Colorectal Cancer (2021)
- The prognostic impact of the tumour stroma fraction (2021)
- TGF-beta-mediated epithelial-mesenchymal transition and tumor-promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma (2021)
- Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation (2021)
- An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation (2021)
- High Density of NRF2 Expression in Malignant Cells Is Associated with Increased Risk of CNS Metastasis in Early-Stage NSCLC (2021)
- Targeting hepatocyte growth factor in epithelial-stromal interactions in an in vitro experimental model of human periodontitis (2021)
- Programmed Cell Death Ligand 1 Expression in Resected Non-Small Cell Lung Cancer (2021)
- PD-L1 expression in gastroenteropancreatic neuroendocrine neoplasms grade 3 (2020)
- Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis (2020)
- Quantitative, qualitative and spatial analysis of lymphocyte infiltration in periampullary and pancreatic adenocarcinoma (2020)
- Topographical Distribution and Spatial Interactions of Innate and Semi-Innate Immune Cells in Pancreatic and Other Periampullary Adenocarcinoma (2020)
- ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma (2020)
- The protein expression profile of ACE2 in human tissues (2020)
- Comprehensive analysis of RNA binding motif protein 3 (RBM3) in non-small cell lung cancer (2020)
- The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model (2020)
- Diagnostic Value of Insulinoma-Associated Protein 1 (INSM1) and Comparison With Established Neuroendocrine Markers in Pulmonary Cancers (2020)
- An immune gene expression signature distinguishes central nervous system metastases from primary tumours in non-small-cell lung cancer (2020)
- A clonal expression biomarker associates with lung cancer mortality (2019)
- LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer (2019)
- Real-world prevalence of programmed death ligand 1 expression in locally advanced or metastatic non small-cell lung cancer (2019)
- Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung (2019)
- Prognostic Impact of Tumor Cell Programmed Death Ligand 1 Expression and Immune Cell Infiltration in NSCLC (2019)
- Programmed Cell Death Ligand 1 Immunohistochemistry (2019)
- A combined gene expression tool for parallel histological prediction and gene fusion detection in non-small cell lung cancer (2019)
- Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11 (2019)
- Mucin staining is of limited value in addition to basic immunohistochemical analyses in the diagnostics of non-small cell lung cancer (2019)
- Cancer stemness, intratumoral heterogeneity, and immune response across cancers (2019)
- NK- and T-cell subsets in malignant mesothelioma patients (2019)
- c-MET as a biomarker in patients with surgically resected non-small cell lung cancer (2019)
- Immunohistochemical profiles in primary lung cancers and epithelial pulmonary metastases (2019)
- 30O Real-world prevalence of PD-L1 expression in locally advanced or metastatic non-small cell lung cancer (NSCLC) (2018)
- Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer (2018)
- COX-2 expression and effects of celecoxib in addition to standard chemotherapy in advanced non-small cell lung cancer. (2018)
- An integrative transcriptome analysis reveals a functional role for thyroid transcription factor-1 in small cell lung cancer (2018)
- LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease (2018)
- Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer (2018)
- Digital multiplex immunofluorescence analysis identifies immune profiles in the tumor stroma associated with clinical outcome (2018)
- Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients (2018)
- Digital pathology 2.0 (2018)
- The Heidelberg compact electron beam ion traps (2018)
- An Integrative Analysis of Transcriptome and Epigenome Features of ASCL1-Positive Lung Adenocarcinomas (2018)
- The Role of TGF- Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis (2018)
- Real-World Prevalence of PD-L1 Expression in Advanced NoneSmall-Cell Lung Cancer (2018)
- Comparison of Three Different TTF-1 Clones in Resected Primary Lung Cancer and Epithelial Pulmonary Metastase (2018)
- Radionuclide Therapy of HER2-Expressing Human Xenografts Using Affibody-Based Peptide Nucleic Acid-Mediated Pretargeting (2018)
- The clinical impact of tumour-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite (2017)
- PD-L1 immunohistochemistry in clinical diagnostics of lung cancer (2017)
- Reaching the limits of prognostication in non-small cell lung cancer (2017)
- Antitumoral effect and reduced systemic toxicity in mice after intra-tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel (2017)
- Integrative CAGE and DNA Methylation Profiling Identify Epigenetically Regulated Genes in NSCLC (2017)
- Establishing Reflex NGS Testing in NSCLC in a Regional Network of County Hospitals in Central Sweden (2017)
- Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer (2017)
- Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification (2017)
- Mutation Profiling by Targeted Next Generation Sequencing of an Unselected NSCLC Cohort (2017)
- Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer (2017)
- PD-L1 immunohistochemistry in clinical diagnostics (2017)
- RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer (2017)
- Antitumoral effect and reduced systemic toxicity in mice after intra-tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel (2017)
- The integrative clinical impact of tumor-infiltrating T lymphocytes and NK cells in relation to B lymphocyte and plasma cell density in esophageal and gastric adenocarcinoma (2017)
- Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity (2017)
- A pathology atlas of the human cancer transcriptome (2017)
- Prognostic impact of tumour-infiltrating B cells and plasma cells in colorectal cancer (2016)
- Profiling cancer testis antigens in non-small-cell lung cancer (2016)
- Prognostic impact of tumour-associated B cells and plasma cells in oesophageal and gastric adenocarcinoma (2016)
- Prognostic impact of tumor-associated B-cells and plasma cells in esophageal and gastric adenocarcinoma (2016)
- Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy (2016)
- Transcriptome analysis of periodontitis-associated fibroblasts by CAGE sequencing identified DLX5 and RUNX2 long variant as novel regulators involved in periodontitis (2016)
- Prognostic impact of tumour-associated B cells and plasma cells in epithelial ovarian cancer (2016)
- Inconsistent results in the analysis of ALK rearrangements in non-small cell lung cancer (2016)
- The Impact of the Fourth Edition of the WHO Classification of Lung Tumours on Histological Classification of Resected Pulmonary NSCCs (2016)
- Fibroblast VEGF-receptor 1 expression as molecular target in periodontitis (2016)
- The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling (2016)
- Various Antibody Clones of Napsin A, Thyroid Transcription Factor 1, and p40 and Comparisons With Cytokeratin 5 and p63 in Histopathologic Diagnostics of Non-Small Cell Lung Carcinoma (2016)
- Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer (2015)
- The Crux of Molecular Prognostications in NSCLC (2015)
- The Identification of Therapeutic Targets in Lung Cancer Based on Transcriptomic and Proteomic Characterization of Cancer-Testis Antigens (2015)
- COX-2 Expression Does Not Predict Outcome of Celecoxib in Addition to Standard Chemotherapy in Advanced Non-Small Cell Lung Cancer (2015)
- The role of the p53 target Wig-1 in senescence and cancer (2015)
- LRIG1 is a prognostic biomarker in non-small cell lung cancer (2015)
- Mutation Profiling by Targeted Next-Generation Sequencing for Diagnostics and Patient Cohort Screening in FFPE NSCLC Samples (2015)
- Immunohistochemistry-based prognostic biomarkers in NSCLC (2015)
- Identification of sample annotation errors in gene expression datasets (2015)
- ALK Rearrangements in Non-Small Cell Lung Cancer (2015)
- Prognostic impact of COX-2 in non-small cell lung cancer (2015)
- Clinical Validation of HaloPlex Targeted Resequencing in Formalin-Fixed, Paraffin-Embedded (FFPE) Cancer Biopsies (2015)
- HaloPlex Targeted Resequencing for Mutation Detection in Clinical Formalin-Fixed, Paraffin-Embedded Tumor Samples (2015)
- Patients with Non-small Cell Lung Cancer Analyzed for EGFR (2015)
- A systematic analysis of commonly used antibodies in cancer diagnostics (2014)
- Genomic and Transcriptional Alterations in Lung Adenocarcinoma in Relation to Smoking History (2014)
- The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling (2014)
- 1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer (2014)
- Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer (2014)
- An Integrative Analysis of the Tumorigenic Role of TAZ in Human Non-Small Cell Lung Cancer (2014)
- Prognostic relevance of cancer-associated fibroblasts in human cancer (2014)
- Biomarker discovery in non-small cell lung cancer (2013)
- Targeted Resequencing of Formalin-Fixed, Paraffin-Embedded (FFPE) Specimens for Mutation Diagnostics in Solid Tumors (2013)
- In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics (2013)
- Interactions between LRIG proteins and LMO7 and the expression of LMO7 in human lung cancer. (2013)
- The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer (2013)
- Genomic and Transcriptional Alterations in Lung Adenocarcinoma in Relation to EGFR and KRAS Mutation Status (2013)
- IGKC and Prognosis in Breast Cancer-Letter (2013)
- Landscape of somatic allelic imbalances and copy number alterations in human lung carcinoma (2013)
- Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors (2012)
- CD99 is a novel prognostic stromal marker in non-small cell lung cancer (2012)
- In vitro autoradiography of carcinoembryonic antigen in tissue from patients with colorectal cancer using multifunctional antibody TF2 and 67/68Ga-labeled haptens by pretargeting (2012)
- Consistent mutation status within histologically heterogeneous lung cancer lesions (2012)
- A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin kappa C as a compatible prognostic marker in human solid tumors (2012)
- Immunoglobulin kappa chain as an immunologic biomarker of prognosis and chemotherapy response in solid tumors (2012)
- Biobanking of fresh frozen tissue from clinical surgical specimens (2011)
- Fresh frozen tissue (2011)
- Targeted resequencing of candidate genes using Selector Probes (2011)
- Traditional European Medicine (2011)
- Gene Copy Number Aberrations Are Associated with Survival in Histologic Subgroups of Non-small Cell Lung Cancer (2011)
- Allele-specific copy number analysis of tumor samples with aneuploidy and tumor heterogeneity (2011)
- Complementary and alternative medicine in lung cancer patients (2010)
- Gene Copy Number Aberrations are Associated with Survival in Histological Subgroups of Non Small Cell Lung Cancer (2010)
- TGF-beta Signaling in Gingival Fibroblast-Epithelial Interaction (2010)
- Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer (2010)
- KRAS analysis in colorectal carcinoma (2010)
- CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth (2009)
- Impact of thawing on RNA integrity and gene expression analysis in fresh frozen tissue (2009)
- Quantification of normal cell fraction and copy number neutral LOH in clinical lung cancer samples using SNP array data (2009)
- TA-MUC1 epitope in non-small cell lung cancer (2009)
- Predictive factors for the use of complementary and alternative medicine (CAM) in radiation oncology (2009)
- Regulation of tyrosine phosphatases in the adventitia during vascular remodelling (2009)
- bFGF rescues imatinib/STI571-induced apoptosis of sis-NIH3T3 fibroblasts. (2009)
- Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer (2009)
- A novel strategy based on histological protein profiling in-silico for identifying potential biomarkers in urinary bladder cancer (2009)
- In vitro characterization of the cytokine profile of the epithelial cell rests of Malassez (2008)
- Dynamic changes in the expression of DEP-1 and other PDGF receptor-antagonizing PTPs during onset and termination of neointima formation (2007)
- An open-label, prospective phase I/II study evaluating the immunogenicity and safety of a ras peptide vaccine plus GM-CSF in patients with non-small cell lung cancer (2007)
- In Situ Identification of Genes Regulated Specifically in Fibroblasts of Human Basal Cell Carcinoma (2007)
- Cytokine profile in synovial fluid from patients with internal derangement of the temporomandibular joint (2006)
- Biobanking of fresh frozen tissue (2006)
- Exploring the tumour environment (2005)
- Laser-assisted cell microdissection using the PALM system. (2005)
- Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate (2004)
- A fluid cover medium provides superior morphology and preserves RNA integrity in tissue sections for laser microdissection and pressure catapulting (2004)
- Tumour-stroma interaction (2004)
- Downregulation of bradykinin B2 receptor in human fibroblasts during prolonged agonist exposure (2003)
- Characterization of c-kit expression in small cell lung cancer (2003)
- Zinc-based fixative improves preservation of genomic DNA and proteins in histoprocessing of human tissues. (2003)
- Extending the immune phenotypes of lung cancer: Oasis in the desert
- Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer.
- Plasma proteomic analysis in non-small cell lung cancer patients treated with PD1/PD-L1 blockade
- COX-2 expression and effects of celecoxib in addition to standard chemotherapy in advanced non-small cell lung cancer.
- Predictors of long-term survival and recurrence patterns after definitive chemoradiotherapy in stage III NSCLC – a multicenter cohort study from Mid Sweden
- Antibody targeting of tumor associated macrophages in lung cancer remodel the tumor microenvironment and revives immune targeting of tumor cells
- Highly selective in situ detection of mutant transcripts with gap-fill padlock probes and superRCA
