Emil Marklund
Postdoktor vid Institutionen för cell- och molekylärbiologi; Molekylär systembiologi
- E-post:
- emil.marklund@icm.uu.se
- Besöksadress:
- Husargatan 3
752 37 UPPSALA - Postadress:
- Box 596
751 24 UPPSALA
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Forskning
Denna text finns inte på svenska, därför visas den engelska versionen.
In my research I am deciphering the molecular mechanisms of life. I am especially interested in how biological macromolecules manage to bind to each other strongly, and with high specificity, so that some pairs of molecules interact with each other while others don't. One important example of such an interaction is sequence specific binding of proteins to DNA, which is essential for regulating gene expression in all life forms. Somehow a DNA binding protein manages to find and bind the correct DNA site by sucessfully discriminating it from the millions of other possible sites in the genome of the cell. To unravel how this is possible we are measuring protein binding and unbinding at grand scale to many DNA sequence mutants simultaneously, and we then use this data to build and test quantitative models of the interaction. My hope and goal is that we will one day be able to understand these processes in precise, mechanistic and quantitative detail. When we do so, this will most likely have deep implications on how we understand cellular regulation, different physiological states, and disease.
Publikationer
Urval av publikationer
- Sequence specificity in DNA binding is mainly governed by association (2022)
- DNA surface exploration and operator bypassing during target search (2020)
Senaste publikationer
- Sequence specificity in DNA binding is mainly governed by association (2022)
- Orientational dynamics of single molecules applied to protein-DNA target search (2020)
- DNA surface exploration and operator bypassing during target search (2020)
- Structure-guided approach to site-specific fluorophore labeling of the lac repressor LacI (2018)
- Real- Time Single Protein Tracking with Polarization Readout using a Confocal Microscope (2017)
Alla publikationer
Artiklar
- Sequence specificity in DNA binding is mainly governed by association (2022)
- DNA surface exploration and operator bypassing during target search (2020)
- Structure-guided approach to site-specific fluorophore labeling of the lac repressor LacI (2018)
- Real- Time Single Protein Tracking with Polarization Readout using a Confocal Microscope (2017)
- Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1 (2017)
- Measuring the Orientation of Single Proteins Interacting with DNA using Fluorescence Polarization Microscopy (2017)
- The helical structure of DNA facilitates binding (2016)