Hua Huang
Forskare vid Institutionen för immunologi, genetik och patologi; Forskningsprogram: Vaskulärbiologi; Forskargrupp Peetra Magnusson
- E-post:
- hua.huang@igp.uu.se
- Besöksadress:
- Dag Hammarskjölds väg 20
751 85 Uppsala - Postadress:
- Rudbecklaboratoriet
751 85 UPPSALA
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Kort presentation
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I am a vascular biologist with a special interest in the function of brain vasculature and their roles in cerebral diseases such as cerebral vascular malformations and brain tumors. Currently, my research focus is cerebral cavernous malformation (also known as cavernomas). We are studying the pathogenesis of CCM and looking for pharmaceutical targets to treat CCM.
Nyckelord
- glioblastoma
- molecular biology
- vascular biology
- vascular malformation
Publikationer
Senaste publikationer
- SproutAngio (2023)
- Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma (2023)
- Inflammation and neutrophil extracellular traps in cerebral cavernous malformation (vol 79, 206, 2022) (2022)
- Inflammation and neutrophil extracellular traps in cerebral cavernous malformation (2022)
- ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma. (2021)
Alla publikationer
Artiklar
- SproutAngio (2023)
- Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma (2023)
- Inflammation and neutrophil extracellular traps in cerebral cavernous malformation (vol 79, 206, 2022) (2022)
- Inflammation and neutrophil extracellular traps in cerebral cavernous malformation (2022)
- ELTD1-deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma. (2021)
- Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma (2021)
- Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing (2021)
- Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/beta-catenin signaling (2020)
- Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy (2020)
- Sunitinib enhances the antitumor responses of agonistic CD40-antibody by reducing MDSCs and synergistically improving endothelial activation and T-cell recruitment (2016)
- Neutrophil Extracellular Traps Accumulate in Peripheral Blood Vessels and Compromise Organ Function in Tumor-Bearing Animals (2015)
- VEGF suppresses T-lymphocyte infiltration in the tumor microenvironment through inhibition of NF-κB-induced endothelial activation (2015)
- Elevated Expression of the C-Type Lectin CD93 in the Glioblastoma Vasculature Regulates Cytoskeletal Rearrangements That Enhance Vessel Function and Reduce Host Survival (2015)
- alpha B-crystallin/HspB5 regulates endothelial-leukocyte interactions by enhancing NF-kappa B-induced up-regulation of adhesion molecules ICAM-1, VCAM-1 and E-selectin (2013)
- alpha B-Crystallin regulates expansion of CD11b(+)Gr-1(+) immature myeloid cells during tumor progression (2013)
- Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization (2012)
- ELTD1 is dispensable for vascular development and tumor angiogenesis
Böcker
