Christel Bergström
Professor at Department of Pharmacy; Molecular Pharmaceutics
- Telephone:
- +46 18 471 41 18
- Mobile phone:
- +46 73 469 76 22
- E-mail:
- christel.bergstrom@farmaci.uu.se
- Visiting address:
- Biomedicinskt Centrum BMC, Husargatan 3
752 37 Uppsala - Postal address:
- Box 580
751 23 UPPSALA
More information is available to staff who log in.
Short presentation
I make use of knowledge of physiological pathways to improve delivery of pharmacologically active compounds to the site of action. With a strong background in pharmaceutics, material sciences, physical chemistry and physiology, I focus on making use of the right tech with a clinical translation in mind from day one. I make use of advanced computational modelling, develop novel in vitro tools and design new drug carriers in my quest for personalized medicines transforming the current healthcare.
Keywords
- absorption
- computational pharmaceutics
- digestion
- drug delivery
- enabling formulations
- personalised medicines
- solubility
- virtual intestine
Research
This text is not available in English, therefore the Swedish version is shown.
Här beskriver jag min forskning:
Publications
Recent publications
- Molecular dynamics study on micelle-small molecule interactions (2024)
- Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a lipolysis and permeation assay (2024)
- Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches (2024)
- Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid lipid-based formulations (2023)
- Development and validation of a porcine artificial colonic mucus model reflecting the properties of native colonic mucus in pigs (2023)
All publications
Articles
- Molecular dynamics study on micelle-small molecule interactions (2024)
- Development and characterization of solid lipid-based formulations (sLBFs) of ritonavir utilizing a lipolysis and permeation assay (2024)
- Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches (2024)
- Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid lipid-based formulations (2023)
- Development and validation of a porcine artificial colonic mucus model reflecting the properties of native colonic mucus in pigs (2023)
- Evaluation in pig of an intestinal administration device for oral peptide delivery (2023)
- Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of lipid-rich solid oral dosage forms (2023)
- Quality attributes for printable emulsion gels and 3D-printed tablets (2023)
- Numerical simulation of peristalsis to study co-localization and intestinal distribution of a macromolecular drug and permeation enhancer (2023)
- Molecular Dynamics Simulations of Self-Assembling Colloids in Fed-State Human Intestinal Fluids and Their Solubilization of Lipophilic Drugs (2023)
- Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms (2022)
- Considerations in the developability of peptides for oral administration when formulated together with transient permeation enhancers (2022)
- Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat (2022)
- Intestinal Absorption of FITC-Dextrans and Macromolecular Model Drugs in the Rat Intestinal Instillation Model (2022)
- Gastrointestinal mucus in dog (2022)
- Intrinsic lipolysis rate for systematic design of lipid-based formulations (2022)
- Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden: Need for personalized dosage forms (2022)
- Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin (2022)
- Comparison of cellular monolayers and an artificial membrane as absorptive membranes in the in vitro lipolysis-permeation assay (2022)
- Membrane insertion mechanism of the caveola coat protein Cavin1 (2022)
- UNGAP best practice for improving solubility data quality of orally administered drugs (2022)
- Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate (2022)
- Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease (2021)
- Physiological properties, composition and structural profiling of porcine gastrointestinal mucus (2021)
- In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery (2021)
- Pharmaceutical Profiling and Molecular Dynamics Simulations Reveal Crystallization Effects in Amorphous Formulations (2021)
- Impact of Simulated Intestinal Fluids on Dissolution, Solution Chemistry, and Membrane Transport of Amorphous Multidrug Formulations (2021)
- Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate (2021)
- Investigation of Self-Emulsifying Drug-Delivery System Interaction with a Biomimetic Membrane under Conditions Relevant to the Small Intestine (2021)
- Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet (2021)
- 3D-printing of solid lipid tablets from emulsion gels (2021)
- TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica (2021)
- Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs (2021)
- Synergistic Computational Modeling Approaches as Team Players in the Game of Solubility Predictions (2021)
- A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research (2021)
- Contemporary formulation development for inhaled pharmaceuticals (2021)
- Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa (2021)
- Celebrating Women in the Pharmaceutical Sciences (2021)
- A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics (2021)
- In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier (2020)
- An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems (2020)
- Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties (2020)
- Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds (2020)
- Insights into Dissolution and Solution Chemistry of Multidrug Formulations of Antihypertensive Drugs (2020)
- Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations (2020)
- Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers (2020)
- Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties (2020)
- Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids (2020)
- Model-Informed Drug Development in Pulmonary Delivery (2020)
- Model-Informed Drug Discovery and Development in Pulmonary Delivery (2020)
- Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa (2020)
- Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media (2020)
- Molecular Drivers of Crystallization Kinetics for Drugs in Supersaturated Aqueous Solutions (2019)
- Effect of lipids on absorption of carvedilol in dogs (2019)
- Fifty-Eight Years and Counting (2019)
- The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers (2019)
- Perspectives in solubility measurement and interpretation (2019)
- Biorelevant intrinsic dissolution profiling in early drug development (2019)
- Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems (2019)
- The Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS) (2019)
- Long-term physical (in)stability of spray-dried amorphous drugs: relationship with glass-forming ability and physicochemical properties (2019)
- Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage (2019)
- Aggregation Behavior of Medium Chain Fatty Acids Studied by Coarse-Grained Molecular Dynamics Simulation (2019)
- Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning (2019)
- Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro (2019)
- Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs? (2019)
- Model-Based Drug Development in Pulmonary Delivery (2019)
- Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations (2018)
- A Modified In Situ Method to Determine Release from a Complex Drug Carrier in Particle-Rich Suspensions (2018)
- Computational prediction of drug solubility in water-based systems (2018)
- Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations (2018)
- Automated assays for thermodynamic (equilibrium) solubility determination. (2018)
- In Vivo Predictive Dissolution and Simulation Workshop Report (2018)
- Amorphous Magnesium Carbonate Nanoparticles with Strong Stabilizing Capability for Amorphous Ibuprofen (2018)
- Controlled Suspensions Enable Rapid Determinations of Intrinsic Dissolution Rate and Apparent Solubility of Poorly Water-Soluble Compounds (2017)
- Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid (2017)
- The Need for Restructuring the Disordered Science of Amorphous Drug Formulations (2017)
- Mechanism-based selection of stabilization strategy for amorphous formulations (2017)
- Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion (2017)
- Substrate and method dependent inhibition of three ABC-transporters (MDR1, BCRP, and MRP2) (2017)
- Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method (2017)
- Enhanced release of poorly water-soluble drugs from synergy between mesoporous magnesium carbonate and polymers (2017)
- Compromised in vitro dissolution and membrane transport of multidrug amorphous formulations. (2016)
- Tools for Early Prediction of Drug Loading in Lipid-Based Formulations (2016)
- Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs (2016)
- Computational prediction of formulation strategies for beyond-rule-of-5 compounds (2016)
- Understanding the Challenge of Beyond-Rule-of-5 Compounds Preface (2016)
- Lipophilicity in Drug Development (2016)
- 50 years of oral lipid-based formulations (2016)
- Rapid determination of drug solubilization versus supersaturation in natural and digested lipids (2016)
- Partitioning into Colloidal Structures of Fasted State Intestinal Fluid Studied by Molecular Dynamics Simulations (2016)
- Diffusion-Controlled Drug Release from the Mesoporous Magnesium Carbonate Upsalite® (2016)
- Supersaturation of poorly soluble drugs induced by mesoporous magnesium carbonate (2016)
- Physical stability of drugs after storage above and below the glass transition temperature (2015)
- Intestinal solubility and absorption of poorly water soluble compounds (2015)
- Computational Prediction of Drug Solubility in Fasted Simulated and Aspirated Human Intestinal Fluid (2015)
- Concomitant intake of alcohol may increase the absorption of poorly soluble drugs (2015)
- Computational modeling to predict the functions and impact of drug transporters (2015)
- Models for Predicting Drug Absorption From Oral Lipid-Based Formulations (2015)
- Computational predictions of glass-forming ability and crystallization tendency of drug molecules (2014)
- Experimental and Computational Prediction of Glass Transition Temperature of Drugs (2014)
- Is the full potential of the biopharmaceutics classification system reached? (2014)
- Early pharmaceutical profiling to predict oral drug absorption (2014)
- Pyridyl Benzamides as a Novel Class of Potent Inhibitors for the Kinetoplastid Trypanosoma brucei (2014)
- Formulation of the Microbicide INP0341 for In Vivo Protection against a Vaginal Challenge by Chlamydia trachomatis (2014)
- Early recognition of absorption challenges of contemporary targets: (2013)
- Early drug development predictions of glass-forming ability and physical stability of drugs (2013)
- Early Identification of Clinically Relevant Drug Interactions with the Human Bile Salt Export Pump (BSEP; ABCB11) (2013)
- Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients (2013)
- Optimizing Solubility and Permeability of a Biopharmaceutics Classification System (BCS) Class 4 Antibiotic Drug Using Lipophilic Fragments Disturbing the Crystal Lattice (2013)
- Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis (2013)
- Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo Dataset (2012)
- Ethanol Effects on Apparent Solubility of Poorly Soluble Drugs in Simulated Intestinal Fluid (2012)
- In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions (2012)
- Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors (2011)
- Toward In Silico Prediction of Glass-Forming Ability from Molecular Structure Alone (2011)
- Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media (2010)
- Interaction of 140 orally administered drugs with the liver-specific organic anion transporter OATP1B1 (SLCO1B1) (2010)
- A Modified Physiological BCS for Prediction of Intestinal Absorption in Drug Discovery (2010)
- Hepatitis C virus NS3 protease inhibitors (2009)
- Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs (2009)
- Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1 (2008)
- Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2) (2008)
- Molecular characteristics for solid-state limited solubility (2008)
- Photoinduced Formation of N2 Molecules in Ammonium Compounds (2007)
- Poorly soluble marketed drugs display solvation limited solubility (2007)
- A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2) (2007)
- Prediction of ADMET Properties. (2006)
- Prediction of ADMET Properties (2006)
- Contribution of solid-state properties to the aqueous solubility of drugs. (2006)
- Computational models to predict aqueous drug solubility, permeability and intestinal absorption (2005)
- X-ray yield and selectively excited X-ray emission spectra of atenolol and nadolol. (2005)
- Theoretical predictions of drug absorption in drug discovery and development (2002)
- Two is better than one: benefits of combining supersaturating and solubilizing effects
- Classification of promiscuous glass-formers: Limitations of differential scanning calorimetry
- The influence of drug loading and drug-polymer interactions on physical stability and supersaturation of spray-dried solid dispersions
- Influence of lipase products and lipolysis-permeation assay formats on drug absorption from lipid-based formulations
- Pickering emulsion gel enables 3D printing of lipid-rich solid oral dosage forms
- Quality attributes of lipid tablets produced by semi-solid extrusion 3D printing: Towards personalized dosage forms in a clinical setting
- Drug solubilization in dog intestinal fluids with and without administration of lipid-rich formulations
- Selective laser sintering 3D printing of personalized dosage forms
Chapters
- How Physicochemical Properties of Drugs Affect Their Metabolism and Clearance (2016)
- Computational absorption prediction (2008)
- Prediction of ADMET Properties (2007)
Conferences
- Advanced methodologies to study in vitro digestion of a lipid-loaded mesoporous drug carrier (2019)
- A new method that enables in situ measurement of drug release from complex carrier-mediated systems (2017)
- Synthesis of amorphous magnesium carbonate nanoparticles for biomedical applications (2017)
- Dissolution studies of solid formulations - Applicability of µDiss inmonitoring supersaturation, nucleation and crystallization behavior; Casestudy: Carrier-based formulation. (2016)
- Diffusion controlled drug release from Mesoprous Magnesium Carbonate (2016)
Patents
